BioTAS™ Plasma Proteomics Workflow Overview
Systems-Level Plasma Measurement. Engineered for Translation.
BioTAS™ is a globally patented, affinity-independent plasma proteomics and phosphoproteomics infrastructure designed for development-stage programs requiring mechanistic resolution and clinical scalability. The platform integrates controlled plasma stabilization, quantitative mass spectrometry, and structured computational modeling to enable reproducible systems-level measurement across decentralized and regulated environments.
Rather than relying on predefined affinity panels, BioTAS™ directly quantifies the dynamic plasma proteome and phosphoproteome, enabling resolution of pharmacodynamic pathway remodeling, target engagement, and treatment-adaptive molecular signatures.
Engineered for structured translational progression, the platform supports advancement from discovery-stage profiling to clinical-scale assay deployment.
Differentiating Capabilities
- Direct mass spectrometry–based quantification without panel constraints
- Parallel measurement of protein abundance and phosphorylation state
- Controlled pre-analytical plasma stabilization to reduce collection variability
- Systems-level modeling of kinase activity and network remodeling
- Infrastructure designed for decentralized study integration and assay transfer
Translational Impact
- Detect pharmacodynamic pathway remodeling in human plasma
- Define mechanism-of-action at systems scale
- Generate treatment-adaptive molecular signatures
- Support companion diagnostic progression
- Enable clinical-scale plasma assay deployment
Performance Summary
Detailed coverage depth, reproducibility metrics, and analytical specifications are provided in the downloadable Technical Brief.