Scientific Resources and Technical Materials
Publications, technical briefs, and supporting materials documenting quantitative proteomic methodologies, analytical performance, and translational execution.
Clinical Demonstration Study
bioRxiv (2026)
Manousopoulou A*, White CH*, et al.
Novel Plasma Proteomics and Phosphoproteomics Platform Captures Pleiotropic Cardiometabolic Spectrum Effects of Semaglutide in Patients with T2D and Atherosclerosis: A Companion Diagnostic Pilot Study from the STOP Randomized Trial.
DOI: https://doi.org/10.64898/2026.02.16.706239
Demonstrates longitudinal systems-level plasma proteomics and phosphoproteomics in a randomized clinical trial, resolving pharmacodynamic network remodeling and enabling companion diagnostic progression.
Peer-Reviewed Publications
Selected publications reflecting proteomic methodologies, analytical performance, and translational applications.
Nat Chem Biol (2026)
Griffin ME, Thompson JW, Xiao Y, et al.
Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates.
DOI: https://doi.org/10.1038/s41589-025-02108-7
Demonstrates systems-level mapping of post-translational modification networks and proteomic interaction profiling.
Nat Cancer (2025)
Rotiroti MC, Tousley AM, Chu H, et al.
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy.
DOI: https://doi.org/10.1038/s43018-025-01056-4
Demonstrates proteomic and signaling analysis supporting cellular immunotherapy development.
JCI Insight (2024)
Schiff HF, Walker NF, Ugarte-Gil C, et al.
Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers.
DOI: https://doi.org/10.1172/jci.insight.173273
Demonstrates plasma proteomics for infectious disease biomarker discovery and diagnostic development.
Cell Rep Med (2022)
Sharpe BP, Hayden A, Manousopoulou A, et al.
Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts.
DOI: https://doi.org/10.1016/j.xcrm.2022.100541
Demonstrates phosphoproteomic pathway analysis defining mechanism-of-action and therapeutic synergy.
eLife (2022)
Ashley B, Simner C, Manousopoulou A, et al.
Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit.
DOI: https://doi.org/10.7554/eLife.71094
Demonstrates systems-level proteomic analysis in maternal–fetal biology and metabolic regulation.
Technical Briefs
Integrated quantitative proteomic and phosphoproteomic infrastructure spanning primary tissue and plasma to support mechanistic discovery, systemic pharmacodynamic evaluation, and translational advancement toward regulated implementation.
BioTAS™ Plasma Proteomics Workflow Overview
BioTAS™ is a globally patented, affinity-independent plasma proteomics and phosphoproteomics infrastructure designed for development-stage programs requiring mechanistic resolution and clinical scalability.
Integrated Quantitative Proteomic and Phosphoproteomic Systems Analysis
Proteas Health delivers integrated quantitative proteomic and phosphoproteomic analysis designed for drug discovery and translational development.